Tamanna started her film career with a Hindi film, Chand Sa Roshan Chehra. She made her debut in Tamil film industry along with Ileana In Kedi which did not do well at the box office. Her debut film in Telugu was Sri in which she played the leading female role opposite Manoj Kumar.
Her Telugu film Happy Days brought her huge success. In Tamil, the movie "Kalloori" won her accolades and critical acclaim. She did a series of films like Netru Indru Naalai , padikathavan but her Tamil project Ayanwas a blockbuster, and it helped her gain fame and establish herself asa leading actress in both telugu and tamil film industries.